Oni is a cell biologist whose graduate research at Cold Spring Harbor Laboratory (CSHL) focused on pancreatic cancer. At CSHL, he helped develop one of the first mouse and human organoid models of pancreatic cancer, then used those models to identify tumor-specific metabolic vulnerabilities and resistance pathways. He also generated antibodies to abnormal proteins on the cell-surface of tumor cells; those antibodies are now being used to develop better methods for detecting pancreatic cancer. At Whitehead Institute, Oni is working to understand the poor antitumor immune response to pancreatic cancer and to develop novel ways of promoting tumor clearance by immune cells.